Maria started writing a mathematics textbook for her siblings, which developed into her most important work, Instituzioni Analitiche (Analytical Institutions), concerning differential and integral calculus. Upon publication in 1748, Maria’s book (dedicated to Empress Maria Theresa of Austria) caused a sensation in academia, being a systematic collation of the works of various mathematicians, along with her own discoveries. It was one of the first and most complete works on finite and infinitesimal analysis, and was translated into several languages to be used as a textbook across Europe.