The United States' longest-serving first lady, Roosevelt was also known for her humanitarian efforts, and had a successful career of her own, something that helped redefine what it meant to be a woman in the political sphere and in the public eye.

Brehanna Daniels, Breanna O'Leary and Dalanda Ouendeno are some of the first women ever to pit in the Daytona 500. "I think that just bringing diversity to the sport, that's how everybody gets better," says O'Leary.

Vivian Lord's letter to toymakers last year caught the attention of Pennsylvania toy manufacturer BMC Toys, which created the special figurines for her.

“Over the past year I’ve been incredibly blessed and humbled by the response to my book, and I’m proud to channel that enthusiasm toward girls around the world,” she said in a statement. “My hope is that this donation will help more bold and brilliant girls reach their fullest potential, continuing upward on their path toward becoming the women they are meant to be.”

Wilma Mankiller faced an uphill battle to achieve her goals as both a woman and a Native American, but she faced the resistance with tenacity, eventually becoming the first woman ever to head the Cherokee nation, one of the country’s largest tribes.

Every summer for the past 800 years, an all-men team of rowers has traveled the River Thames in England counting swans as part of an ancient royal ceremony known as Swan Upping. That all changed last week, however, when Karen Hammond became the first woman since the 12th century to take part in the ritual, which involves counting, weighing and tagging baby swans between Sunbury-on-Thames and Abingdon Bridge

“I’m their biggest cheerleader when helping them achieve their goals. I try not to miss a beat in their lives. I take the responsibility of being their father very seriously and never for granted.”

This Changes Everything also features Natalie Portman, Reese Witherspoon, Taraji P. Henson, Cate Blanchett among others